When growing microbes or animal cells in a stirred tank reactor it is critical to choose the impeller type that is best suited to your process Select the wrong impeller and you could make chop suey of your filamentous fungi Pick the right impeller and you could greatly increase yields of your fussy mammalian cultures such as Chinese hamster ovary CHO and Vero kidney epithelial cells
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Bioreactors Fermenters Function Designs and types Fermenter design was considerably improved during 1940s to accommodate the requirements of strict aseptic conditions and good agitation and aeration for penicillin production from submerged cultures for this steel fermenters with working volumes of 54 000 1 were built in U S A
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nbsp 0183 32 Aeration System Spargers • A sparger may be defined as a device for introducing air into the liquid in a fermenter • Three basic types of sparger have been used and may be described as the Porous sparger the Orifice sparger a perforated pipe and the Nozzle sparger an open or partially closed pipe 47 48
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Open turbines of variable pitch Propellers Stirrer glands and bearings Four basic types of seal assembly Stuffing box • Shaft is sealed by several layers of packing rings of asbestos or cotton Orifice Sparger • It is a perforated pipe kept below the impeller in the form
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CLASSIFICATION Disc turbine Vaned disc Variable pitch open turbine Marine propellers 12 DISC TURBINE A disc with series of rectangular vanes set in a vertical plane around the circumference Break up a fast air stream without itself becoming flooded in air bubbles SPARGER TYPES Porous Orifice …
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A pressure cycle fermenter with large dimensions constitutes a tower bioreactor Fig 19 2B A high hydrostatic pressure generated at the bottom of the reactor increases the solubility of O 2 in the medium At the top of the riser with expanded top reduces pressure and facilitates expulsion of CO 2 The medium flows back in the down comer and completes the cycle
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nbsp 0183 32 Disc Turbine It consists of a disc with a series of rectangular vanes connected in a vertical plane around the disc Vaned disc In this case the rectangular vanes are attached vertically to the underside of a disc Variable Pitch open turbine This type of agitator lacks disc and the vanes are directly connected to a center shaft
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Basic Design of a Ferment Er Free ebook download as Powerpoint Presentation ppt pptx PDF File pdf Text File txt or view presentation slides online book
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Fermenter Design A bioreactor is a device in which a substrate of low value is utilized by living cells or enzymes to generate a product of higher value Open turbines of variable pitch Propellers 2 Spargers are of the following three basic types Porous spargers Orifice spargers Nozzle spargers
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Open turbines of variable pitch Propellers Stirrer glands and bearings Four basic types of seal assembly Stuffing box • Shaft is sealed by several layers of packing rings of asbestos or cotton Orifice Sparger • It is a perforated pipe kept below the impeller in the form
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In later modifications mechanical impellers were used to improve mixing of broth and dispersal of air bubbles Fermenter design was considerably improved during 1940s to accommodate the requirements of strict aseptic conditions and good agitation and aeration for penicillin production from submerged cultures for this steel fermenters with working volumes of 54 000 1 were built in U S A
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Overview of Fermentation Process Bioprocess Principles Free ebook download as Powerpoint Presentation ppt PDF File pdf Text File txt or view presentation slides online Anna University B Tech Biotechnology Bio process Principles UNIT I
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Types of Agitators Disc turbine Vaned disc Open turbine variable pitch Marine impeller Introduction Contd RT 3 RT 4 RT 5 RT 6 RT 12 RT 8 Types Rushton turbine Introduction Contd • Shuler M L and F Kargi Bioprocess Engineering Basic Concepts 2nd ed Prentice Hall Upper Saddle River NJ 2002 References
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3 Agitator impeller Agitator is required to achieve a no of mixing objectives • Bulk fluid and gas phase mixing • Air dispersion • Oxygen transfer • Heat transfer • suspension of solid particles • maintaining a uniform environment throughout the vessel contents Agitator may be classified as Disc turbine vaned discs open turbine of variable pitch and propellers
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PDF On Ranjan Singh and others published BIO PROCESS TECHNOLOGY AN INTRODUCTION TO FERMENTORS Find read and cite all the research you need on ResearchGate
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Bioreactor Also known as Fermenter A bioreactor is a specially designed vessel which is built to support the growth of high concentration of microorganisms It must be so designed that it is able to provide the optimum environments or conditions that will …
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3 Agitator impeller Agitator is required to achieve a no of mixing objectives • Bulk fluid and gas phase mixing • Air dispersion • Oxygen transfer • Heat transfer • suspension of solid particles • maintaining a uniform environment throughout the vessel contents Agitator may be classified as Disc turbine vaned discs open turbine of variable pitch and propellers
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Fermenter Design pdf 14302pmqyg4j Pharmacologyonline 1 301 2010 Newsletter Jagani et al An Overview of Fermenter and the Design Considerations to Enhance Its Productivity Hitesh Jagani Karteek Hebbar Sagar S Gang P Vasanth Raj Raghu Chandrashekhar H and J Venkata Rao
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CLASSIFICATION Disc turbine Vaned disc Variable pitch open turbine Marine propellers 12 DISC TURBINE A disc with series of rectangular vanes set in a vertical plane around the circumference Break up a fast air stream without itself becoming flooded in air bubbles SPARGER TYPES Porous Orifice …
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There are three basic types of valve swing check lift check and combined stop and check with a number of variants The swing check valve Fig 7 37 is most commonly used in fermenter designs The functional part is a hinged disc which closes against a seat ring when the intended direction of flow is accidentally reversed
Leave A Message1 Agitator Impeller These objectives are achieved by a suitable combination of from CHEM 1002 at VIT University
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Bioreactors Fermenters Function Designs and Types Free download as PDF File pdf Text File txt or read online for free reactors
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Types of Impellers in Centrifugal Pumps Impeller design is the most significant factor for determining performance of a centrifugal pump A properly designed impeller optimizes flow while minimizing turbulence and maximizing efficiency The impeller of a centrifugal pump can be of three basic types
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